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Which mechanism hinders pharmaceutical drug permeation across cell membranes?

A)Intermolecular hydrogen bonding affinity
B)Intramolecular carbon bond saturation
C)Van der Waals radius reduction
D)Pi-stacking orbital delocalization

💡 Explanation

Intermolecular hydrogen bonding lowers drug permeation because hydrogen bonds between drug molecules increases aggregate size, limiting diffusion, therefore reducing passage, rather than options involving intramolecular activity and altering molecular radii impacting membrane interaction.

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