Which mechanism primarily explains why aggregated amyloid-beta proteins are cleared from the brain more slowly with increasing age, impacting cognitive function?

💡 Explanation

Impaired microglial phagocytosis and autophagy lead to decreased amyloid-beta clearance because these processes are essential for removing protein aggregates. Therefore, reduced microglial function results in slower clearance, rather than increased cerebrospinal fluid or blood-brain barrier permeability enhancing removal.

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