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Which mechanism reduces peptide bond rotational freedom within proteins?

A)Steric hindrance of bulky sidechains
B)Electrostatic repulsion between charged groups
C)Hydrogen bonding with solvent molecules
D)Hydrophobic collapse of the polypeptide

💡 Explanation

Steric hindrance restricts rotation because atoms clash during rotation. This effect, via steric repulsion, limits confirmations. Therefore, steric restrictions, rather than other bonding forms, dictate protein structure due to spatial constraints.

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