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← Nature & AnimalsWhich metabolic shift impairs brown adipose tissue function during arousal from hibernation?
A)Decreased uncoupling protein-1 (UCP1) expression
B)Increased fatty acid synthesis via lipogenesis
C)Enhanced glucose oxidation inhibiting lipolysis✓
D)Elevated ketone body production causing acidosis
💡 Explanation
During hibernation arousal, if glucose oxidation is pathologically enhanced over uninhibited lipolysis, normal thermogenesis from brown adipose tissue is impaired because UCP1 requires fatty acids to allow proton leak across the mitochondrial inner membrane. Therefore, enhanced glucose oxidation inhibits lipolysis rather than UCP1 decreasing or ketone production both require different pathways.
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