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Which outcome arises when a cooling solution compromises transmembrane alpha-helix integrity?

A)Protein misfolding and aggregation increases
B)Lipid bilayer fluidity significantly rises
C)Covalent bond hydrolysis accelerates greatly
D)Unsaturated phospholipid synthesis rate increases

💡 Explanation

Protein misfolding and aggregation rises because hydrophobic collapse occurs when the integrity of the transmembrane alpha-helix is compromised, losing stability via weakened Van der Waals interactions. Consequent misfolded proteins interact, rather than folding correctly, therefore triggering unwanted intermolecular aggregation and dysfunctional protein interactions.

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