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Which outcome arises when molecular interactions limit pharmaceutical dissolution?

A)Excipient degradation accelerates rapidly
B)Bioavailability becomes greatly reduced
C)Hydrolysis reaction generates undesired products
D)Polymorphism initiates unintended crystallization

💡 Explanation

Reduced bioavailability appears, because strong intermolecular attractions encourage aggregation, limiting surface area, and, therefore, limiting the rate of dissolution rather than faster degradation, hydrolysis or crystallization which require alternative conditions.

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