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← ScienceWhich outcome determines the rate of drug metabolism reactions involving Cytochrome P450?
A)Enzyme-substrate binding affinity✓
B)Gastric acid concentration increase
C)Hepatic blood flow resistance
D)Renal tubular filtration dynamics
💡 Explanation
The rate is limited by enzyme-substrate affinity because Michaelis-Menten kinetics dictates that enzyme velocity depends on binding, therefore stronger affinity results in faster reaction, rather than blood flow which affects delivery of the drug.
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