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← ScienceWhich outcome occurs when a desiccant fails during pharmaceutical lyophilization?
A)Product collapse during phase transition✓
B)Accelerated rate of vacuum pump failure
C)Increased sublimation rate from product
D)Rise in chamber oxygen concentration
💡 Explanation
Product collapse happens because the desiccant's failure to maintain dryness enables ice crystal reformation during sublimation from water reabsorption; the mechanism is glass transition. Therefore, the product collapses rather than sublimates completely or risks vacuum pump failure.
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