Which outcome occurs when a misfolded protein evades proteasomal degradation?

💡 Explanation

Amyloid plaque forms, triggered by proteasome failure. Protein aggregation results from a disruption in proteostasis via nucleation; because the ubiquitin-proteasome system fails, the misfolded protein aggregates extracellularly. Aggregation rather than endocytosis occurs because proteasomes recycle misfolded intracellular molecules.

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