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← ScienceWhich outcome occurs when a pharmaceutical protein exceeds the glass transition temperature?
A)Amorphous structure becomes more crystalline
B)Covalent bonds degrade due to oxidation
C)Increased protein unfolding and aggregation✓
D)Hydrogen bonds reinforce native tertiary structure
💡 Explanation
Protein unfolding and aggregation increases with temperature because exceeding glass transition increases molecular mobility; therefore proteins unfold and aggregate, rather than crystallizing,remaining stable, or breaking covalent bonds.
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