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← ScienceWhich outcome occurs when a pharmaceutical protein folds incorrectly in solution?
A)Aggregation through hydrophobic interactions occurs✓
B)Ester hydrolysis decreases molecular rigidity
C)Covalent dimer formation is stabilized
D)Peptide sequence inversion happens rapidly
💡 Explanation
Aggregation arises because hydrophobic collapse drives non-native associations between protein molecules with exposed hydrophobic patches. This leads to protein clumping, therefore aggregation dominates rather than ester hydrolysis which requires catalysts.
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