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Which outcome occurs when a semi-permeable microfiltration membrane encounters excessive transmembrane pressure in protein separation?

A)Molecular compaction induces concentration polarization
B)Increased diffusion eliminates concentration gradients
C)Reduced viscosity lowers back transport
D)Enhanced solubility reverses protein aggregation

💡 Explanation

Molecular compaction favors accumulation because concentration polarization is a phenomenon where solute buildup near the membrane increases osmotic pressure, therefore flux declines rapidly rather than remaining constant, because of pressure and compaction overpowering diffusion.

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