Which outcome occurs when an enzyme's active site conformation destabilizes?

💡 Explanation

Substrate binding affinity decreases because the destabilized active site causes the Enzyme-substrate complex to form less effectively by increasing the free energy of binding. Therefore, reducing substrate binding is expected, rather than lowering the activation energy directly.

• Which outcome occurs when solid catalyst's surface area accessible to reactants decreases during exothermic reaction?
• Which mechanism causes increased embrittlement when interstitial hydrogen concentrates in a metal lattice?
• Which outcome results from exceeding the Lawson criterion in deuterium-tritium fusion?
• Which consequence results when moisture weakens epoxy-amine thermoset polymer?
• Which consequence results when uneven epoxy coating thickness induces chromatic effects on fiber optic cables?
• Which outcome occurs when a positive displacement pump attempts to transfer a fluid held above its critical temperature?