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Which outcome occurs when inhibiting hexokinase within erythrocytes?

A)Decreased glycolysis, ATP production declines
B)Increased pentose phosphate pathway flux
C)Elevated NADPH levels, reduced oxidative stress
D)Enhanced osmotic stability, preventing hemolysis

💡 Explanation

Inhibiting hexokinase reduces glucose-6-phosphate production; therefore, decreased glycolysis arises because the initial irreversible commitment step is blocked. This directly limits the entire pathway and thus ATP production declines rather than flux adjusting through alternatives.

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