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Which outcome occurs when prolonged cold exposure depletes glycogen?

A)Ineffective non-shivering thermogenesis
B)Decrease in metabolic water release
C)Increased lactate fermentation rate
D)Complete ATP synthase deactivation

💡 Explanation

Ineffective non-shivering thermogenesis results because the depletion of liver glycogen inhibits cellular respiration pathways fueling the uncoupling protein 1 channel in the mitochondria, which generates heat rather than ATP; therefore, shivering is stimulated prior to depletion rather than afterward.

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