Which outcome results from polypeptide chain misfolding because of disrupted hydrophobic interactions near transmembrane alpha-helices?

💡 Explanation

Aggregation and plaque formation occur due to exposed hydrophobic amino acids promoting intermolecular interactions through hydrophobic collapse, rather than proper folding promoting correct interactions, because secondary structures and chaperone functionalities are overwhelmed; therefore, pathological aggregation ensues.

• Which outcome results when an unstable isotope undergoes alpha decay?
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• Which risk increases when overlapping atomic orbitals destabilize bonding?