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Human Body & Health

Which process compromises an immune cell in rheumatoid arthritis?

A)Complement-mediated cell lysis
B)Thymic negative selection failure
C)Defective MHC molecule presentation
D)Regulatory T cell dysfunction

💡 Explanation

In rheumatoid arthritis, immune complexes activate the complement system, and the resulting cascade causes complement-mediated cell lysis of cells in the joints, because the generated membrane attack complex causes cell rupture. Therefore, cell lysis intensifies inflammation, rather than limiting expansion by T-cell regulation.

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