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Which process inhibits protein function during amyloid fibril formation?

A)Aberrant hydrogen bond network disruption
B)Electrostatic repulsion reduction
C)Increased hydrophobic residue availability
D)Enhanced disulfide bridge crosslinking

💡 Explanation

Aberrant unfolding exposes hydrophobic regions, triggering intermolecular hydrogen bonding, leading to misfolded aggregates because amyloid formation involves disrupted native structure's intricate hydrogen bond network; therefore option A is right, rather than alternatives involving stronger native interactions

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