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Which process modifies orbital hybridization during enzymatic catalysis?

A)Local electric field changes
B)Vibrational mode quantum tunneling
C)Solvent thermal diffusion changes
D)Substrate-mediated pi-stacking distortion

💡 Explanation

Orbital hybridization changes because shifting electron density alters electrostatic interactions via **electric field induction**. Therefore, orbital shapes mold to accommodate the transition state, rather than resulting purely from vibrational modes or solvent effects.

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