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Which risk increases for a pharmaceutical compound following molecular crystallization?

A)Reduced bioavailability in drug product
B)Increased oxidation from atmospheric exposure
C)Accelerated degradation under accelerated testing
D)Enhanced binding affinity to target proteins

💡 Explanation

Poorly soluble crystal forms reduce drug absorption following dissolution because decreased surface area limits dissolution rate according to the Noyes-Whitney equation; therefore bioavailability is decreased, rather than increased oxidation affecting stability under typical storage conditions.

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