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← ScienceWhich risk increases when asymmetric molecular bond breakage occurs during drug metabolism?
A)Increased therapeutic effect efficacy
B)Formation of toxic metabolites✓
C)Enhanced drug bioavailability occurs
D)Reduced cytochrome P450 inhibition
💡 Explanation
The formation of toxic metabolites increases because heterolytic cleavage, a type of asymmetric bond breakage, results in unequal electron distribution, promoting reactive electrophiles, rather than favoring stable products, therefore leading to toxicity under physiological conditions.
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