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Which risk increases when flash-freezing biological samples transitions too slowly?

A)Extracellular ice crystal formation expands
B)Intracellular vitrification inhibits enzymes
C)Molecular vibration decreases entropy
D)Metabolic rate decreases exponentially

💡 Explanation

Extracellular ice crystal formation expands because slow phase transitions favor the gradual growth of ice crystals in the extracellular medium rather than rapid intracellular vitrification; therefore, larger extracellular crystals risk damaging cellular structures rather than vitrifying intracellular contents.

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