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Human Body & Health

Why does a subsequent exposure to pollen provoke a stronger allergic reaction in sensitized individuals compared to the initial exposure?

A)Decreased T helper cell activation occurs
B)Eosinophils immediately neutralize the allergens
C)Innate immunity prevents mast cell degranulation
D)IgE antibodies trigger mast cell degranulation

💡 Explanation

Subsequent exposure elicits a faster, stronger response because the sensitization phase induces IgE production that binds to mast cells; therefore, re-exposure triggers rapid mast cell degranulation and histamine release, rather than the slower initial immune response.

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