Why does administering a drug that inhibits prostaglandin synthesis reduce fever caused by a bacterial infection?

💡 Explanation

Prostaglandins mediate the hypothalamus's response to pyrogens, which are fever-inducing substances released during bacterial infections. Blocking prostaglandin synthesis reduces the hypothalamic sensitivity to these pyrogens, therefore lowering the body's temperature; rather than addressing the infection directly or affecting vasodilation.

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