Why does antibody-dependent cellular cytotoxicity (ADCC) by NK cells sometimes fail to eliminate cancer cells despite apparent antibody binding?

💡 Explanation

Cancer cells can evade ADCC by shedding the surface antigens that antibodies bind to, because this reduces the effectiveness of NK cell activation; therefore, ADCC fails, rather than NK cells being overwhelmed by complement or other immune suppressive mechanisms.

• Why does shivering, rather than sweating, begin when an anesthetized patient's core body temperature drops below the hypothalamic set point?
• If an individual repeatedly uses an addictive substance, which consequence results in the mesolimbic pathway?
• If a researcher selectively inhibited GLP-1 receptor signaling in the arcuate nucleus of the hypothalamus, which consequence follows regarding appetite regulation?
• Why does a patient with a duodenal switch bariatric surgery maintain satiety despite a reduced stomach size?
• Why does glossitis occur in pellagra sufferers more readily than in individuals with sufficient niacin intake?
• What distinguishes lymphatic drainage in tissues surrounding tumors compared to healthy tissues, under similar interstitial pressure?