Why does cellular senescence increase in aging muscle tissue, contributing to sarcopenia?

💡 Explanation

Cellular senescence increases due to progressive telomere shortening, triggering DNA damage response pathways that halt cell division; because of this accumulation of senescent cells and decline in muscle regeneration capacity, sarcopenia advances. Therefore, telomere shortening is the primary driver, rather than increased ATP production, satellite cell activation, or mTOR signaling.

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