Why does chronic inflammation persist even when initial triggers subside, specifically concerning the prostaglandin pathway?

💡 Explanation

Chronic inflammation can persist because NF-kB activation, a key step in the prostaglandin pathway, establishes positive feedback loops amplifying its own signaling. These loops sustain inflammation even without continuous external stimuli; therefore, inflammation continues, rather than resolving due to receptor desensitization or component degradation.

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