Why does chronic psoriasis lead to weakened skin integrity and increased risk of secondary infections, despite increased keratinocyte proliferation?

💡 Explanation

Psoriasis causes rapid keratinocyte proliferation, but the resulting keratin is structurally abnormal. This abnormal keratin structure disrupts the normal stratum corneum architecture; therefore, the skin barrier function is impaired, increasing susceptibility to infection, rather than providing effective protection like healthy skin.

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