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Human Body & Health

Why does declining inhibin production frequently result in elevated FSH levels during a woman's perimenopause?

A)Granulosa cell apoptosis increases directly
B)Pituitary gland sensitivity decreases sharply
C)Negative feedback on pituitary reduces
D)LH secretion becomes constitutively active

💡 Explanation

Reduced inhibin from aging ovaries lessens negative feedback on the pituitary gland, causing it to secrete more FSH, because inhibin normally suppresses FSH. Therefore, FSH elevates to stimulate the ovaries, rather than LH secretion becoming constitutively active.

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