Why does excessive fibrinolysis increase the risk of hemorrhage following tissue plasminogen activator (tPA) administration for stroke?

💡 Explanation

Excessive fibrinolysis breaks down existing fibrin clots, which are crucial for hemostasis after injury; tPA promotes plasminogen activation to plasmin, causing fibrin degradation. Because tPA enhances fibrinolysis, the risk of hemorrhage increases due to the breakdown of stable clots, therefore option D is correct, rather than the other options which involve different aspects of clot formation or stability.

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