Why does immobilization of a fractured tibia lead to increased bone resorption around the fracture site, impacting the remodeling process?

💡 Explanation

Bone remodeling adapts to mechanical stress; decreased loading inhibits mechanotransduction, reducing osteoblast activity and increasing osteoclast activity. Because of this imbalance, bone resorption exceeds bone formation. Therefore, immobilization increases bone resorption rather than stimulating osteogenesis through hormonal pathways.

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