Why does localized atherosclerosis in arteries often lead to systemic hypertension rather than remaining a localized pressure effect?

💡 Explanation

Systemic hypertension results from atherosclerosis because reduced blood flow to the kidneys activates the renin-angiotensin-aldosterone system (RAAS), elevating systemic blood pressure. Therefore, RAAS activation causes a systemic effect rather than localized changes, because this hormonal cascade affects the entire cardiovascular system.

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