Why does prolonged stimulation of vagal afferents by GLP-1 reduce appetite despite the homeostatic drive to eat?

💡 Explanation

Prolonged stimulation of vagal afferents by GLP-1 leads to increased satiety signaling in the brain, promoting feelings of fullness and reducing appetite. This occurs because GLP-1 receptor activation enhances satiety signals, such as increased CCK and PYY release, therefore decreasing food intake, rather than direct reward pathway inhibition alone.

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