Why does selective neuronal death occur in specific brain regions during neurodegenerative diseases like Alzheimer's, rather than uniform brain-wide damage?

💡 Explanation

The selective vulnerability of brain regions in neurodegenerative diseases arises because regional autophagy, the process of clearing misfolded proteins and damaged organelles, differs in efficiency across brain areas; therefore, some regions accumulate toxic aggregates faster, rather than uniform global damage, due to diverse cellular stressors.

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