Why does thyroxine production remain elevated despite high circulating thyroid hormone levels in individuals with thyroid hormone resistance syndrome?

💡 Explanation

Because thyroid hormone resistance syndrome results from mutations in thyroid hormone receptors, the receptors are less responsive to thyroid hormones; therefore, the hypothalamus and pituitary fail to sense high levels, resulting in continued TSH release and elevated thyroxine production, rather than normal negative feedback inhibition.

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