A patient's renal tubules exhibit impaired Tamm-Horsfall protein production. Which consequence follows, considering calcium oxalate and uric acid supersaturation in the kidneys?

💡 Explanation

Impaired Tamm-Horsfall protein reduces its ability to inhibit calcium oxalate and uric acid crystallization because it normally binds to these crystals preventing their growth and aggregation. Therefore, kidney stone formation risk increases, rather than sodium reabsorption, phosphate excretion, or renin secretion changes.

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