A patient with chronic anemia has a blood pH of 7.2, resulting from increased anaerobic metabolism. Which effect dominates hemoglobin's oxygen-binding affinity in this condition?

💡 Explanation

A lower pH (more acidic) promotes the Bohr effect, causing a decrease in hemoglobin's oxygen affinity because hydrogen ions bind to hemoglobin, stabilizing the T-state. Therefore, oxygen is released more readily to tissues rather than exhibiting increased affinity or altered 2,3-BPG binding.

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