A patient with severe anemia receives a blood transfusion stored for several weeks. Which risk increases as the level of 2,3-BPG decreases in the stored blood cells?

💡 Explanation

The risk of reduced oxygen release to tissues increases because 2,3-BPG normally reduces hemoglobin's affinity for oxygen. A decrease in 2,3-BPG causes hemoglobin to bind oxygen more tightly, therefore less oxygen is released to tissues, rather than enhancing oxygen binding or altering CO2 transport.

• A patient exhibiting hyperoxaluria is prescribed potassium citrate. If the concentration of citrate in the renal filtrate increases, which consequence follows?
• Why does sustained hypertension typically lead to increased fluid filtration into tissues and peripheral edema?
• If a burn wound disrupts keratinocyte migration due to compromised fibronectin matrix deposition in the extracellular matrix, which consequence follows, assuming the wound remains sterile?
• If a patient develops type 2 diabetes despite consistently injecting insulin, which mechanism involving GLUT4 transporters primarily explains this resistance at the cellular level?
• If a person exercising intensely on a hot, humid day stops abruptly, which consequence related to thermoregulation follows?
• What happens to immune system function when regulatory T cells fail in the thymus during negative selection?