A patient with severe seasonal allergies undergoes allergen immunotherapy. If the treatment successfully reduces allergic symptoms upon pollen exposure, which effect dominates regarding histamine?

💡 Explanation

Successful allergen immunotherapy reduces the activation of mast cells by allergen-IgE complexes, reducing histamine release; because the crosslinking of IgE receptors triggers mast cell degranulation. Therefore, reduced mast cell degranulation occurs, rather than increased histamine synthesis or clearance, which wouldn't alleviate allergic symptoms.

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