A person with a genetic defect has normal B-cells but non-functional helper T-cells. Which immunological effect results when they are exposed to a novel bacterial pathogen?

💡 Explanation

Impaired helper T-cell function compromises B-cell activation and subsequent antibody production, because T-cell cytokines are required for efficient B-cell clonal selection and differentiation. Therefore, specific antibody production is impaired, rather than class switching or cell proliferation which depend on T-cell help.

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