If a football player experiences a rotational head impact, which cascade explains why diffuse axonal injury occurs, exceeding cellular strain tolerance?

💡 Explanation

When rotational forces act on the brain, shear strain occurs. Because the brain tissue deforms unevenly, this strain disrupts the axonal cytoskeleton, leading to axonal injury. Therefore, cytoskeletal disruption is the correct answer, rather than ATP reversal or microglial activation, which are not direct consequences of shear strain.

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