A previously healthy individual receives a kidney transplant. Despite initial immune suppression, chronic rejection occurs over several years. Why does this rejection process accelerate despite ongoing immunosuppression?

💡 Explanation

The rejection accelerates because antibody-mediated injury amplifies inflammation through complement activation and Fc receptor engagement on innate immune cells, therefore increasing tissue damage. This process circumvents initial T-cell suppression, rather than being directly controlled by T-cells; because the antibody production sustains inflammation, rather than antigen halting.

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