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Life Sciences & Medicine

A protein destined for the mitochondrial matrix contains a targeting sequence. Which outcome occurs when the TOM/TIM complex malfunctions in protein import?

A)Protein misfolds in the cytosol
B)Protein accumulates in the ER lumen
C)Protein enters peroxisome normally
D)Protein remains in the cytosol

💡 Explanation

If the TOM/TIM complex malfunctions, the protein cannot be transported into the mitochondrial matrix via protein translocation, because the complex is essential for import. Therefore, the protein remains in the cytosol, rather than being imported or mislocalized to other organelles.

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