After starting norepinephrine infusion following severe sepsis, which consequence results from increased downstream arteriolar constriction?

💡 Explanation

When norepinephrine constricts arterioles, increased vascular resistance results in decreased blood flow to the kidneys and glomerular filtration rate because of reduced hydrostatic pressure. This phenomenon occurs rather than augmenting tissue perfusion at nephrons; therefore kidney cells are exposed to less arterial blood.

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