If a patient experiences repeated low-dose allergen exposures without immediate anaphylaxis, why might the subsequent exposure trigger a more severe allergic reaction?

💡 Explanation

The subsequent exposure triggers a more severe reaction because the repeated low-dose allergen exposures lead to IgE-mediated mast cell sensitization. This process primes mast cells by binding IgE to their surface, therefore, subsequent allergen binding causes massive degranulation rather than a limited response. T-helper suppression would reduce reaction severity.

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