An individual with rheumatoid arthritis takes a COX-2 selective inhibitor. Which outcome is most likely observed regarding prostaglandin production in the inflamed joints?

💡 Explanation

COX-2 selective inhibitors reduce prostaglandin E2 synthesis because they specifically target cyclooxygenase-2, an enzyme crucial for PGE2 production in inflammation. Therefore, PGE2 production decreases, rather than an increase in thromboxane or other inflammatory mediators, which are regulated by different pathways.

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