Why does chronic histamine exposure during asthma exacerbations contribute to airway remodeling?

💡 Explanation

Histamine promotes collagen deposition by fibroblasts via H1 receptor activation; because this leads to extracellular matrix protein accumulation, it directly causes airway wall thickening and fibrosis (remodeling). Therefore, the correct answer is D, rather than A, B, or C which involve opposite or unrelated effects.

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