A researcher investigates insulin resistance in adipocytes by inhibiting IRS-1 phosphorylation. Which consequence follows regarding GLUT4 translocation when insulin binds its receptor?

💡 Explanation

Inhibiting IRS-1 phosphorylation disrupts the insulin signaling cascade, because IRS-1 is crucial for activating downstream pathways that promote GLUT4 translocation. Consequently, GLUT4 vesicles cannot effectively fuse with the plasma membrane, thereby preventing glucose uptake, rather than docking or alternative pathways like glycogen synthase activation occurring.

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