If a patient's inflammatory response to a lung infection continues unabated, failing to transition to the resolution phase, which consequence involving cytokine signaling is most likely?

💡 Explanation

Macrophage phagocytosis of debris is essential for the resolution of inflammation, removing dead cells and tissue damage components. The failure of the inflammatory response to resolve impairs this clearance because the transition from pro-inflammatory to pro-resolution signaling, driven partly by cytokines, is disrupted; therefore, macrophage phagocytosis will be impaired, rather than enhanced as initial inflammation continues unabated.

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