Following a pulmonary infection, why does alveolar inflammation resolve, rather than progressing into chronic fibrosis?

💡 Explanation

Resolution of inflammation involves a shift from pro-inflammatory prostaglandins and leukotrienes to specialized pro-resolving mediators (SPMs) like lipoxins and resolvins. These SPMs actively promote immune cell apoptosis and efferocytosis. Therefore, lipoxin and resolvin signaling drives resolution, rather than unchecked fibrosis stimulated by factors like TGF-beta.

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